Best B12 Supplement for 2022 (Reviews & Buyer’s Guide)

Best B12 Supplement

If you’ve been tired despite getting enough rest, chances are you’re dealing with a B12 deficiency. But how to find the best B12 supplement for you? We’re here to lend a helping hand!

What we did was round up the best offers available right now based on effectiveness, quality of ingredients, value, and user reviews. We included an in-depth guide, too, to provide you with all the details you need to make an informed decision.

Let’s get to it!

The Best B12 Supplement: A Quick Overview

Key Features
Expert Review
  • Overall best B12 supplement
  • 5,000 mcg per serving
  • Over 13,000 positive ratings
  • Eco-friendly packaging
FROM: $ 29.95
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  • Best B12 sublingual supplement
  • Highly potent liquid B12
  • 3rd party tested
  • 1-year money-back guarantee
FROM: $ 24.95
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Expert Review
  • Best among absorbable B12 supplements
  • USDA-certified organic
  • 100% vegan
  • No fillers or synthetic ingredients
FROM: $ 24.95
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Expert Review
  • Best liquid B12 for the whole family
  • Delicious natural berry flavor
  • Easy-to-use spray bottle
  • 100% happiness guarantee
FROM: $ 23.95
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  • Most transparent and best vitamin B12 brand to buy
  • Natural mixed berry flavor
  • Gluten-free and vegan
  • 1-year return policy
FROM: $ 12.95
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  • Best B12 supplement for energy
  • Can help with MTHFR gene mutation
  • Superior customer service
  • 60-day satisfaction guarantee
FROM: $ 19.95
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  • Best tasting vitamin B12 supplement
  • All-natural ingredients
  • Supports bone and heart health
  • Easy on the digestive system
FROM: $ 18.99
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Expert Review
  • Best vitamin B12 complex
  • Certified vegan and kosher
  • Tested for 125+ herbicides and pesticides
  • Combined with real-food
FROM: $ 31.76
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  • Best vitamin B12 gummies
  • Delicious and easy-to-consume
  • Perfect starting dose for B12 vitamins
  • Clean and fresh ingredients
FROM: $ 12.52
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  • Best vitamin B12 supplement brand
  • USP verified for label accuracy and purity
  • Science-based product
  • Inexpensive (60 ct. for less than $20)
FROM: $ 18.99
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Top Ten Vitamin B12 Reviews

Jarrow Formulas Methyl B12 Cherry

  • Editor’s Choice: Best B12 supplement on the market
  • Type: Chewable tablets
  • B12 per Serving: 5,000 mcg
  • Servings per Container: 60
  • Shipping and Return Policy: Free; 60-day
  • Price: From $29.95

What makes Jarrow Formulas Methyl B12 Cherry our top choice for the best vitamin B12 supplement?

First off, it’s made by a highly reputable brand that has been in the business of supplements since 1977, so you know that you’re getting safety, quality, and purity.

What’s more, Jarrow Formulas B12 supplements are formulated with the purest and most active form of the vitamin — the naturally-occurring methylcobalamin. From boosting energy to regulating sleep-wake cycles, Methyl B12 delivers all the health benefits of this vitamin quickly and effectively. 

Another feature that puts this product on our best quality B12 supplement list is the taste. Jarrow Formulas Methyl B12 comes in two more flavors — lemon and tropical, and it tastes delicious without the help of artificial coloring, flavoring, or added sugar.

Finally, the Methyl B12 tablets are incredibly easy to consume. Users can chew or dissolve these tablets, which is especially helpful to older adults and children who might have a hard time swallowing pills.  

A great price, excellent quality, fantastic taste, and noticeable effects — Jarrow Formulas Methyl B12 provides all this and more. No wonder it tops multiple reviews as the best B12 methylcobalamin supplement. 

  • No gluten, soy, or wheat
  • Free shipping
  • Great value
  • The dosage of 5,000 mcg per serving might be too potent for some users

LiveWell Vegan B12

  • Editor’s Choice: Best B12 supplement to take sublingually
  • Type: Liquid
  • B12 per Serving: 5,000 mcg
  • Servings per Container: 60
  • Shipping and Return Policy: Free on bundles and repeat deliveries; 365-day
  • Price: From $24.95

LiveWell Vegan B12 contains the most bioavailable and natural form of B12 (methylcobalamin) in the fastest-acting form — a sublingual liquid. It is also one of the most potent B12 supplements on the market, packing an impressive 5,000 mcg per serving.

Rated as the best B12 supplement in sublingual form, LiveWell Vegan B12 supports the metabolic and nervous system, provides energy, and improves cellular reproduction. Simply put, it supports all the processes that are vital to your overall wellbeing. 

You won’t find any gluten, dairy, or fillers in this supplement. Even the delicious citrus flavor is derived from organic extracts, so it’s 100% safe and natural like all LiveWell’s supplements, from the best magnesium pills to its top-rated joint health supplements. 

LiveWell Vegan B12 is a highly potent, fast-acting, and the most effective B12 supplement. Try it today, and you won’t regret it.

  • 2-month supply with each bottle
  • No soy, gluten, dairy, GMO, or preservatives
  • Made in the US
  • Potential dosing difficulties
  • Customer-reported itching after using the product

Global Healing Center B12 Blend

  • Editor’s Choice: Best source of highly absorbable B12 supplement
  • Type: Liquid
  • B12 per Serving: 2,500 mcg (blend) and 5,000 mcg (tri-blend)
  • Servings per Container: 1 oz and 2 oz bottles
  • Shipping and Return Policy: Free; 365-day
  • Price: $24.95–$39.95

When it comes to the best B12 supplement absorption, nothing beats Global Healing Center B12 Blend. 

Made from the purest and most bioavailable form of B12 (a combination of methylcobalamin and adenosylcobalamin), this 100% organic supplement delivers B12 directly to the bloodstream for faster effects. 

You could also opt for the tri-blend option. Not only does it contain a combination of methylcobalamin and adenosylcobalamin, but it also introduces hydroxocobalamin into the mix. What’s more, it comes with 5,000 mcg of B12 per serving for sustained support.

Not only does it take effect quickly, but Global Healing Center B12 Blend is also free of synthetic compounds and fillers. Using only natural and necessary ingredients, it’s suitable for vegans, vegetarians, and people with allergies. 

The best B12 supplement reviews simply rave about this organic supplement. Over 1,700 happy customers love this product and promote it as a great energy booster and mood enhancer. What’s more, this supplement promotes restful sleep. 

Formulated with everything you need to battle B12 deficiency, the B12 Blend is an excellent choice for any user.

  • Effective and bioactive formula
  • No alcohol, gluten, GMO, soy, or harsh chemicals
  • Easy to use
  • Can be too sweet for some users
  • Several B12 supplements reviews complain about changes in ingredients

Mary Ruth’s Organic Methyl B12 Spray

  • Editor’s Choice: Best liquid vitamin B12 supplement for an entire family
  • Type: Spray
  • B12 per Serving: 1,500 mcg
  • Servings per Container: 120
  • Shipping and Return Policy: Free on orders over $49.00; 90-day
  • Price: $23.95–$45.50

Formulated with clean, natural ingredients, Mary Ruth’s Organic Methyl B12 Spray is the best vegan B12 supplement for the whole family. 

This premium product only contains the purest and most active form of B12 — methylcobalamin. Known as the most bioavailable and fastest-acting type of B12, methyl can help people with MTHFR gene variants and aid your brain, cells, and nerves. 

Mary Ruth’s Organic Methyl B12 Spray delivers around 3,000 mcg of B12 a day — an extra-strong dose for a natural boost of energy and improved focus. It’s sold in an easy-to-use and convenient 1-oz spray bottle. It also comes with a yummy and sweet berry flavor, making consumption of this top B12 supplement even easier. 

Free of gluten, harmful materials, or added sugars, the Organic Methyl B12 spray is a fantastic natural solution for B12 deficiency for everyone in the family.

  • Celiac- and keto-friendly
  • USDA-certified organic
  • One of the best-rated liquid B12 supplements and best sublingual vitamin B12
  • On the pricier side
  • A few users say that the bottle leaks and stains

Amazon Elements Vitamin B12

  • Editor’s Choice: Best B12 vitamin brand with incredible transparency
  • Type: Lozenges
  • B12 per Serving: 5,000 mcg
  • Servings per Container: 65
  • Shipping and Return Policy: Free on orders over $25.00; 365-day
  • Price: From $12.95

Amazon Elements Vitamin B12 is another high-dosage supplement designed to meet the B12 requirements of almost any user. 

Offering 5,000 mcg of methyl B12 per serving, this supplement can boost energy production, promote healthy cognitive function, and support the immune system. 

Potent and incredibly tasty, these lozenges are easy to consume, too, as verified by more than one B12 supplement review

Still, quality assurance is the area where this brand really shines. 

Amazon Elements goes above and beyond in its dedication to transparency and safety. Each batch is tested for purity and quality. Furthermore, lab results are available for each user to check by scanning the bottle’s QR code. 

Users looking for a trusted brand, high-potency dosage, and absorbable vitamins will find what they need and more with Amazon Elements Vitamin B12.

  • 3rd party tested for purity and quality
  • Great value according to numerous vitamin B12 supplement reviews
  • No artificial colors, flavors, or chemical preservatives
  • Not suitable for people sensitive to sugar alcohol (contains xylitol and mannitol)
  • Might not dissolve as well

Seeking Health Active B12 with L-5-MTHF

  • Editor’s Choice: Vitamin B12 best supplement for an energy boost
  • Type: Lozenges
  • B12 per Serving: 1,000 mcg
  • Servings per Container: 60
  • Shipping and Return Policy: Free; 60-day
  • Price: From $19.95

Active B12 with L-5-MTHF by Seeking Health combines the best B12 vitamins with active folate for even more health benefits. 

B12 is derived from two active “coenzyme” forms of the vitamin — methylcobalamin and adenosylcobalamin. The folate, on the other hand, comes in the form of L-5-methyltetrahydrofolate, considered the most prevalent form of folate in the body. 

Together they play a major role in homocysteine regulation. Homocysteine is an amino acid, high levels of which can contribute to arterial damage and blood clots. 

Vitamin B12 reviews by users praise this supplement as a natural remedy for fatigue and lethargy, saying that it has significantly increased their energy levels, attention span, and focus. 

So, if you’re looking for two active vitamins for the price of one, don’t hesitate to give Active B12 with L-5-MTHF a try.

  • The best B12 vitamin for energy
  • Crafted with the help of a healthcare professional
  • CoAs are available upon request
  • Some users are not happy with the natural cherry taste
  • Might cause sleep disruption if a dosage is too high

SBR Nutrition Vitamin B12

  • Editor’s Choice: Best B12 supplement with an unmatched taste
  • Type: Liquid
  • B12 per Serving: 3,000 mcg
  • Servings per Container: 60
  • Shipping and Return Policy: Free; 90-day
  • Price: From $18.99

Affordable and delicious, SBR Nutrition Vitamin B12 is one of the best vitamin B12 supplements available right now. 

One of the features that make this product special is the higher potency. Providing 3,000 mcg of methylcobalamin per serving, SBR Nutrition Vitamin B12 increases energy, improves cardiovascular function, and aids bone health. 

Not only is this supplement healthy, but it’s 100% safe as well. It’s crafted with natural compounds, so there are no GMOs, harmful materials, or unnecessary fillers. Even the taste is enriched with a natural cherry-flavored blend and stevia to add sweetness and make consumption much easier. 

Countless user reviews endorse SBR Nutrition Vitamin B12 as the best B12 supplement for vegans, praising its ease of use and unmatched candy-like flavor. 

If these characteristics tick your boxes, then your search for the best B12 vitamin is over.

  • Maximum absorption
  • Made in a US-based, FDA-compliant facility
  • Great price
  • Some users report that the supplement tastes watered-down
  • Most users describe it as only average

MegaFood Methyl B12

  • Editor’s Choice: Best B12 vitamins to take in a blend
  • Type: Tablets
  • B12 per Serving: 500 mcg
  • Servings per Container: 60 and 90
  • Shipping and Return Policy: Free; 30-day
  • Price: $31.76–$40.56

For those searching for a bit more than B12 in their daily supplements, MegaFood Methyl B12 is an excellent choice. 

In addition to the best B12 supplementmethylcobalamin, this product contains 8 mg of B6 (per serving), folate (L-5-MTHF with broccoli), beetroot, and other nutrients. All these ingredients work together to support the heart, promote blood health, and nourish the body.  

MegaFood Methyl B12 has been tested by independent labs and certified as GMO-, gluten-, and glyphosate residue-free. All compounds are derived from reliable sources, and they are rigorously tested — a practice the company implements on all its products, including its high-rated multivitamins and best-selling prenatal supplements. 

Since this supplement is chock-full of nutrients, it’s safe to consume even on an empty stomach, so you can take the easy-to-swallow tablet any time of the day. 

Combining whole-food goodness with premium B vitamins, this supplement boasts raving vitamin B12 reviews.

  • No GMO, gluten, or soy
  • Supports heart and blood health
  • Compounds sourced from trusted farmers
  • A bit costly for the given quantity
  • The dosage might be too low for some users

Country Life B12 Gummies

  • Editor’s Choice: Best chewable B12 supplements for gummy fanciers
  • Type: Gummies
  • B12 per Serving: 850 mcg
  • Servings per Container: 60 and 120
  • Shipping and Return Policy: Free on orders over $25.00; 30-day
  • Price: $12.52–$20.99

Want to make the best B12 vitamin supplement feel like a treat? Try Country Life B12 Gummies — one of the tastiest and easiest ways to consume B12.

These strawberry-flavored gummies are formulated with 850 mcg of B12 per serving — an ideal dose for someone just starting with vitamin supplements. 

The method of delivery is also perfect for newbies. There is no need to take pesky pills or bother with liquid dosing when you can just chew one of these yummy gummies and get your required dose of B12 for the day. 

Bear in mind that this product contains cane sugar (like most gummies do), so it’s not the ideal choice for users on a strict low-calorie diet. That aside, Country Life B12 Gummies is the most convenient, healthiest, and ultimately the best B12 supplement for a vegan with a sweet tooth.

  • No wheat, gluten, or soy
  • No artificial colors
  • Vegan-friendly
  • Contains added sugar
  • Contains cyanocobalamin and tree nuts (coconut)

Nature Made Vitamin B12 Softgels

  • Editor’s Choice: Best B12 supplement brand
  • Type: Softgels
  • B12 per Serving: 5,000 mcg
  • Servings per Container: 60
  • Shipping and Return Policy: Free; visit Online Return Center to find out your options
  • Price: From $18.99

Founded in 1971, Nature Made has an extensive product line consisting of over 150 vitamins, minerals, and supplements. It’s reputable, pharmacist-recommended, and verified by the United States Pharmacopeia (USP) — all the qualities the best B12 supplement brand should have. 

Nature Made offers a great variety of vitamin B12 supplements. Still, we have chosen the Maximum Strength Vitamin B12 Softgels as the best option. 

Formulated with a whopping 5,000 mcg of B12 per serving, this supplement is affordable, safe, and, most importantly, effective. As a matter of fact, multiple user reviews comment that they’ve seen a considerable increase in daily energy levels after taking this product. 

Actually, over 2,000 customers highly recommend Nature Made Maximum Strength Softgels as the best vit B12 supplement and an excellent solution for B12 deficiency.

  • 3rd party tested
  • Free of gluten, synthetic dyes, flavors, and preservatives
  • Vegetarian-friendly
  • Contains cyanocobalamin
  • Not suitable for vegans because of the gelatin
  • Not ideal for people with soy allergies

The Ultimate Buyer’s Guide to the Best B12 Supplement

Vitamin B12 or cobalamin is one of the most essential vitamins the body needs to perform a number of vital processes. It supports cognitive function, the production of red blood cells, DNA synthesis, as well as brain and heart health. Since the body doesn’t produce B12, you must get it through food and supplements. But before you start ordering B12 vitamins online, there are few things to consider. 

Why is this vitamin so important? How serious is B12 deficiency? And most importantly, how to choose the best vitamin B12 supplement for you? Check out our guide for the answers and more. 

Benefits of Vitamin B12

Vitamin B12 is known to:

  • Increase energy levels
  • Boost memory and cognitive abilities 
  • Improve mood 
  • Promote bone health 
  • Prevent anemia
  • Support eye health and lower the risk of macular degeneration 
  • Support a healthy pregnancy 
  • Promote healthy skin and hair 

Sources of Vitamin B12

B12 is commonly found in animal-based products, such as fish, meat, eggs, and dairy. Some fortified cereals and nutritional yeast products can also provide the body with B12. However, the amounts might not be enough to meet adult cobalamin requirements. 

Signs of a B12 Deficiency

Here are some of the most common signs that you need to take a high-quality vitamin B12 supplement:

  • Weakness and fatigue
  • Loss of appetite 
  • Megaloblastic anemia
  • Depression
  • Cognitive and balance issues 

B12 deficiency can affect anyone, no matter how much vitamin-rich food you eat. In fact, it’s estimated that between 1.5% and 15% of the general population have a B12 deficiency. Still, certain groups might need B12 vitamins and supplements more than others. These include:

  • Older adults 
  • People with stomach and gastrointestinal issues
  • Patients recovering from gastrointestinal surgeries 
  • Vegans and vegetarians 
  • Those taking medication for chronic heartburn

How to Choose the Best B12 Supplement for You?

Let’s take a look at the factors you need to consider when choosing the best vitamin supplement for you or your family member.

Delivery Method

Vitamin B12 supplements come in several forms, from traditional tablets to chewable lozenges and sublingual sprays. 

  • Capsule-based supplements are the most commonly used. They deliver an accurate dosage each time, so there is no need to worry about underdosing. However, pills are not everyone’s favorite. Even the best B12 tablets might be hard to swallow, especially for the elderly, who are most likely to suffer from vitamin B12 deficiency in the first place. 
  • Gummies, like capsules, deliver a consistent dosage with each piece but are much easier to consume due to their candy-like nature. The downside is that other ingredients are often involved in the manufacturing of gummies, including artificial sweeteners, colors, and flavors, which doesn’t exactly make them the best natural B12 supplement. 
  • Liquid supplements are an excellent choice for people who want to get their daily dose of B12 with their morning protein shake. Some B12 liquid supplements are designed to be taken sublingually (under the tongue). Although these are the most bioavailable options, you should be careful with dosing. Unlike tablets and gummies, with liquids, you have to rely on the dropper, which is not always the most accurate dosing method. 

All forms of B12 have advantages and disadvantages. In the end, it’s up to you to choose the best type of B12 depending on preferences, budget, and convenience. 

The Right Dosage 

The recommended daily allowance for adults is 2.4 mcg. Bear in mind that this is the minimum recommended amount, so don’t be alarmed if you see a higher dosage on the supplement packaging. B12 is generally safe even when taken in larger doses. Like other water-soluble vitamins, the body will excrete the amount it can’t absorb through the urine. Nevertheless, you should always discuss possible side effects and dosage with your doctor before taking any supplements.  

Other Ingredients

The best B12 supplements should only contain pure and effective ingredients. Steer clear of fillers, GMOs, and allergens, such as wheat, soy, or nuts. Try to go for organic compounds and stick to clean and simple formulas that will provide the right dosage of B12 without any unnecessary ingredients thrown in the mix. 


The price of a high-quality B12 supplement ranges between $14.99 and $29.95. You could even get the vitamins for less if you take advantage of deals and other buying perks. Most supplement manufacturers offer seasonal sales, coupon codes, and discounts on bundles, so make sure you check out all the company’s offers before clicking the order button. 

User Experiences

Always look at what other customers are saying about the product. B12 supplement reviews will tell you pretty much everything about the effects of the vitamins, as well as provide you with insight into the manufacturer and its policies and practices.

Wrapping It Up

We understand how overwhelming it could be to find a good B12 supplement. Available products on the market range from low-dosage tablets to high-potency liquids and sprays, making the selection process quite challenging. We hope that our reviews of the best supplements have helped narrow down your choice to one premium product that will meet all your B12 needs.


What is the best time to take a B12 supplement?

Since B12 boosts energy and cognitive abilities, it’s best to take the supplement in the morning on an empty stomach and start your day the right way. 

What is the best mcg of B12 to take?

The recommended daily dose is 2.4 mcg, although you can safely take higher doses as the body will excrete any excess.  

How much B12 should you take a day?

Most supplements contain between 500 mcg and 1,000 mcg per serving, which is more than enough to tackle B12 deficiency. 

Which form of vitamin B12 is best?

B12 supplements are usually derived from two sources — cyanocobalamin or methylcobalamin. These two compounds have a similar molecular structure, but the most significant difference is that methylcobalamin is naturally found in food, while cyanocobalamin is a synthetic form of B12. Even though both have the same effects (they can both prevent B12 deficiency), methylcobalamin is the preferred form of the best B12 supplement as it has a higher retention rate and is natural rather than man-made.