Best Berberine Supplement for 2022 (Reviews & Buyer’s Guide)

Best Berberine Supplements

Are you searching for the best berberine supplement to help keep your blood sugar, cholesterol,  or weight in check? If so, then you’re in luck! After conducting extensive research, we gathered a handful of the most popular products on the market and carefully reviewed each one of them for you.

Besides presenting you with detailed reviews, we’ve also included an in-depth guide to berberine supplements. Hopefully, by the end of this article, we’ll have answered all of your questions and concerns about this naturally occurring compound. Please keep reading to discover which of these brands can best complement your lifestyle.

The Best Berberine Supplement Products

Key Features
Expert Review
  • 1200mg Berberine HCl
  • 3rd party lab tested for purity
  • Non-GMO and natural
FROM: $ 40.00
Visit Site
Expert Review
  • Supports healthy blood sugar and lipid levels
  • Enriched with calcium and chromium
  • Gluten-free
FROM: $ 49.99
Visit Site
Expert Review
  • 500mg Berberine HCl
  • Allergen-free
  • Magnesium stearate-free
FROM: $ 36.00
Visit Site
Expert Review
  • No gluten, soy, or artificial colors
  • 1000mg Berberine HCl
  • Very easy to swallow
FROM: $ 13.99
Visit Site
Expert Review
  • 400mg berberine HCl
  • Best source of berberine (97%)
  • Tested for purity and quality
FROM: $ 13.37
Visit Site
Expert Review
  • 600mg berberine HCl
  • Vegan-friendly
  • Gluten-free
FROM: $ 19.95
Visit Site
Expert Review
  • Vegetarian and dairy-free
  • 1200mg berberine HCl extract
  • Soy and dairy-free
FROM: $ 21.95
Visit Site
Expert Review
  • 400mg Oregon Grape extract
  • 400mg Barberry extract
  • 100mg Goldenseal extract
  • Contains alkaloids, including hydrastine
FROM: $ 30.15
Visit Site

Our Top Berberine Supplement Reviews

Nuzena Berberine Pure +

  • Editor’s pick: Best high potency berberine
  • Available in: 60 capsules
  • Amount per Serving: 1200mg
  • Price: $40.00
  • Discounts: No ongoing deals
  • Shipping Policy: Free shipping on orders over $50.00

Compared to other brands in our best berberine supplements reviews, Nuzena’s Berberine Pure + has the most potent berberine formula (1200mg per serving). Besides its superior potency, this is also a top-notch supplement in terms of quality. For instance, we were impressed that it’s gluten-free, GMO-free, and even suitable for our beloved vegan readers.

Scientific research suggests that Nuzena’s berberine formula can reduce blood sugar levels in people with type-2 diabetes, boost metabolism, and help lower cholesterol levels. With science on their side and being on many top 10 lists for the best berberine supplement, we had to score this one high.

Furthermore, we must praise Nuzena’s dedication to providing their customers with the highest quality products. Proof of their commitment is the Nuzena Quality Certification that anyone can access on the company’s official website.

All in all, we recommend Nuzena Berberine Pure+ due to its clinically proven ingredients, efficient and pure extracts, and allergen-free formulas. As a bonus, all of their products are sustainably sourced.

  • Exceptionally potent formula
  • Sustainably sourced high-quality berberine
  • Backed by scientific evidence
  • May cause slight gastrointestinal distress

Whitaker Nutrition Berberine + GlucoGOLD Review

  • Editor's Pick: Overall best berberine supplement
  • Available in: 90 tablets
  • Amount per Serving: 500 mg
  • Price: $49.99
  • Discounts: Email subscription
  • Shipping Policy: Free for orders over $20.00

What makes Whitaker Nutrition the best berberine brand overall, besides 35 years of experience, is a successful clinical study that proves this product is excellent for supporting blood sugar health. Added calcium, chromium, and cinnamon make the blend even more powerful.

Numerous positive Whitaker Nutrition Berberine GlucoGOLD reviews confirm the supplement is very quick and efficient in lowering blood sugar levels and even helping with weight loss. Moreover, the pills also provide support for healthy total and LDL cholesterol levels. Finally, the blend also enhances liver health.

Berberine reviews for diabetes reveal that many doctors prescribe this supplement to their diabetic patients and get very quick results, with patients reporting reduced glare sensitivity and normalized insulin resistance.

However, if you don’t follow your doctor’s recommendations or manufacturer’s instructions, you might end up with diarrhea. This isn’t a catastrophic issue and can be easily avoided by not exceeding the recommended dosage.

  • Promotes weight loss
  • Handles insulin resistance
  • Enhances metabolic and liver health
  • May cause stomach issues

Thorne Research Berberine 500

  • Editor’s pick: Best berberine supplement for regulating blood glucose levels
  • Available in: 60 capsules
  • Amount per Serving: 1000mg
  • Price: $36.00
  • Discounts: A combo offer to save $3.00
  • Shipping Policy: Free shipping on orders over $20.00

Thorne Research Berberine-500 has stellar customer reviews claiming that this is the best natural solution for regulating blood glucose levels. Additionally, Thorne offers a Berbecap option to help balance cholesterol, making it the best berberine supplement with 500mg capsules.

The Berberine-500 formula offers 85% Berberis Concentrate Berberine HCl derived from Barberry extracts. Furthermore, if you suffer from food intolerances or allergies, this could be the brand for you! It’s yeast-free, dairy-free, soy-free, corn-free, and sugar-free. Also, there’s no magnesium stearate (a common food additive) in this supplement.

Each serving (two capsules) will give you 1000mg of pure berberine extract, and it’ll last you for up to one month. Compared to other similar products on the market, this is a moderately high dosage. So, make sure to read the instructions or the information on the official website for the correct dosage.

The only downside is that this supplement is a bit too strong and may keep you awake for longer than you’d like.

  • No artificial preservatives
  • Magnesium stearate-free
  • High concentration of berberis HCl
  • May interfere with sleep schedule

Amazing Nutrition Amazing Formulas Berberine

  • Editor’s pick: Best berberine supplement for PCOS
  • Available in: 60, 120, 250, 360 capsules
  • Amount per Serving: 1000mg
  • Price: From $13.99
  • Discounts: Save up to 5% on auto-deliveries
  • Shipping Policy: Free shipping on orders over $25.00

Amazing Nutrition Berberine offers 500mg of Berberine Hydrochloride (HCl) for glucose metabolism support and weight loss management. Each 1000mg serving consists of two easy-to-swallow gelatin capsules free of common allergens, including peanuts, wheat, soy, fish, eggs, shellfish, and dairy.

There are many reasons why we recommend purchasing this high quality berberine supplement brand. Not only is the quality outstanding, but the manufacturer is also extremely transparent when it comes to the ingredients of their product.

There are many positive ratings about this brand’s ability to help with high blood sugar, lethargy, and weight loss. But what struck us was the many women who swear by this product’s ability to alleviate their symptoms of polycystic ovary syndrome (PCOS). Therefore, we believe Amazing Nutrition is the best berberine supplement with 500mg capsules to treat women with PCOS.

The only negative comments that we spotted were that some users complained that the capsules had a slightly unpleasant odor.

  • Easy on the stomach
  • Detox support
  • Free of common allergens
  • The capsules have a slightly unpleasant odor

Swanson Berberine

  • Editor’s pick: Best berberine brand for budget buyers
  • Available in: 60 capsules
  • Amount per Serving: 400mg
  • Price: From $13.37
  • Discounts: Save 14%–19% on bundles
  • Shipping Policy: Free shipping on orders over $25.00

If you’re entirely new to the world of supplements, we recommend choosing berberine with lower milligrams per capsule. This way, you can easily adjust your body to the strength and dosages. Swanson Vitamins Berberine with 400mg of berberine HCl per serving could be the perfect brand for you.

However, don’t let the low dosage fool you. This premium berberine supplement for diabetes contains 97% berberine HCl derived from berberis aristata root. Even though the dosage is lower than other products, its concentration is high, so you should be careful when using it daily. As always, it’s best to consult with a healthcare professional for expert advice.

Each of Swanson’s products is manufactured in a GMP-certified facility, ensuring complete purity and incredible potency. Moreover, every Swanson product gets tested by an independent and third-party laboratory.

All in all, there are many reasons why we recommend this organic berberine supplement for our readers. In addition to this product’s impressive purity, we also loved its bargain price.

The only negative claims were that some customers felt achieving noticeable benefits took time with this product. So, don’t be discouraged if you don’t notice any significant changes when first beginning supplementation.

  • Low dose but a high concentration of berberine HCl
  • Tested for purity
  • Budget-friendly
  • The supplement takes time to be effective

Nutricost Berberine HCI 600mg

  • Editor’s pick: Best berberine for weight loss
  • Available in: 60 capsules
  • Amount per Serving: 600mg
  • Price: From $19.95
  • Discounts: No ongoing deals
  • Shipping Policy: Free on orders over $25.00

Berberine HCl Capsules by Nutricost are one of the best-selling supplements that you can get for a mere $0.35 per serving. The amount of berberine HCl is relatively low compared to similar products, so it’s a good supplement for beginners. Furthermore, we believe this is an excellent option for people trying to lose weight.

According to many berberine supplement reviews, each container of this supplement will last you up to two months of continuous use. This means that you won’t have to worry about restocking your supply too frequently.

Besides the exceptional production quality, satisfied customers raved about the kind and helpful customer service they received. Someone is always available to answer your questions about what many deem the best berberine on the market.

Lastly, this is a third-party lab-tested, non-GMO, gluten and allergen-free product. The only drawback we came across was that the ingredients include vegetable magnesium stearate, a food additive that many comparable products successfully evade.

  • Suitable for people with sensitive stomachs
  • Neat vegetable flavor
  • Third-party lab-tested
  • Contains magnesium stearate

Sunergetic Premium Berberine

  • Editor’s pick: Best berberine supplement for heart health
  • Available in: 60 capsules
  • Amount per Serving: 1200mg
  • Price: $21.95
  • Discounts: Subscribe and save 5%–10%
  • Shipping Policy: Free on orders over $25.00

Sunergetic Premium offers you a potent 1200mg dose of berberine HCl extract per serving, consisting of two easy-to-swallow vegetable capsules.

Although this brand provides many of the usual benefits of berberine supplements, we believe that it’s the most suitable for our readers who want to support overall wellness and cardiovascular health.

Most studies on berberine indicate a recommended daily dosage of between 1,000 and 1,500 milligrams. Therefore, Sunergetic is a terrific option as just two capsules a day will put you well within this suggested range. Furthermore, many satisfied customers spoke of how they purchased this product to get their blood sugar levels under control and were completely satisfied with the results.

Not only are all Sunergetic products manufactured in an FDA-registered facility, but they’re also GMO-free, yeast-free, corn-free, dairy-free, soy-free, and preservative-free. So, for just over $20, you’ll receive one of the highest-quality berberine brands on the market.

The only negative thing that we can say about Sunergetic Premium is that the exact concentration purity is not listed on the label. However, Sunergetic is a trustworthy brand that has been in the natural supplement business since 2012.

  • Powerful formula
  • Non-GMO
  • Allergen-free
  • Berberine concentration not listed on the label

Integrative Therapeutics Berberine Complex

  • Editor’s pick: Berberine best brand with berberine complex
  • Available in: 90 capsules
  • Amount per Serving: 900mg berberine complex
  • Price: $30.15
  • Discounts: Subscribe and save 5%–10%
  • Shipping Policy: Free on orders over $25.00

If you’re having complications due to small intestinal bacterial overgrowth (SIBO), this is likely the best brand of berberine supplement to provide you with the relief that you need.

Integrative Therapeutics’ unique formula contains a blend of extracts from three different plants, Oregon grape, goldenseal, and barberry. Not only does this mix of multiple extracts offer berberine, but it also provides other beneficial compounds such as hydrastine.

Moreover, research shows that hydrastine in goldenseal is beneficial for skin health. Therefore, we believe this is the best berberine mix supplement and a superb choice for people looking for healthier skin and anti-aging benefits.

Most importantly, this berberine complex doesn’t contain animal by-products, so it’s suitable for our vegan and vegetarian readers. Furthermore, it’s gluten-free, soy-free, dairy-free, artificial color and flavor-free, wheat-free, and preservative-free, making Integrative Therapeutics a superb option for people with food allergies or intolerances.

The only possible disadvantage of this formula is that it contains a complex mix of extracts instead of only berberine HCl. If this bothers you, we suggest choosing another quality supplement from our list of berberine supplement reviews. Either way, for the overall value, we believe this is an exceptional product to consider.

  • Contains three different sources of berberine
  • Contains hydrastine for antiseptic benefits
  • Allergen-free formula
  • Contains a mix of extracts, not just berberine HCI

Best Berberine Supplement User’s Guide

Are you new to the world of berberine supplements? Or do you just want to brush up on your knowledge of using organic berberine for specific health conditions? Whatever the case may be, we’re happy to present you with our buyer’s guide to bring you up to speed.

What is Berberine?

Berberine is a natural plant compound (alkaloid) found in several plants, including the European barberry, goldenseal, and Oregon grape.

This natural compound was widely accepted as a medicine for various health conditions in Ancient China. In recent years, contemporary science has provided some evidence for the extraordinary benefits of berberine.

Organic Berberine Benefits

Research has shown that berberine supplements can have various positive results when used correctly. Some of these benefits include:

  • Lower blood sugar levels (effective treatment for type-2 diabetes)
  • Weight loss (berberine potentially regulates molecules that control fat burning and fat production, like insulin)
  • Antidepressant
  • Anti-inflammation
  • Decreased fatigue
  • Decreased insulin resistance
  • Reduced risk of heart disease
  • Reduced risk of polycystic ovary syndrome (PCOS)
  • Reduced cholesterol levels
  • Reduced progression of cancer
  • Antiviral benefits
  • May help prevent damage to the kidneys
  • May heal canker sores
  • Neuroprotective (helps protect against dementia and other diseases of the mind)
  • Treatment for small intestine bacterial overgrowth or SIBO

Most commonly, healthcare professionals recommend berberine products for the following health conditions:

  • Diabetes and pre-diabetes
  • Hypertension or high blood pressure
  • Insulin resistance
  • Metabolic syndrome
  • Cardiovascular disease
  • Cancer
  • Depression
  • Dyslipidemia

IMPORTANT NOTICE: Even when taking the best quality berberine, always consult your doctor to obtain the most accurate dosage for your specific health condition. Never attempt to self-medicate!

Berberine Side Effects

Although relatively rare, berberine can cause adverse reactions in the body, especially when taken in abnormal doses. However, we feel that it’s important to note that medical experts highly recommend not to take berberine while pregnant or breastfeeding.

 The most common side effects include:

  • Berberine can negatively interact with medications (if you already take medication to regulate blood sugar levels, berberine may cause an additional decrease)
  • Berberine can cause digestive issues (diarrhea or cramps)

Proper Dosage and Best Time to Take Berberine

According to experts, users should spread out their berberine supplement dosage throughout the day to achieve the best results. The reason for this is that berberine is only effective for a couple of hours. Clinical studies indicate that people typically used dosages from 900mg to up to 1500mg a day.

Adults with diabetes are recommended to take between 0.9-1.5g of berberine in divided doses per day for up to 4 months. In comparison, people with high cholesterol levels should take between 0.6-1.5g of the compound in divided doses per day for up to 24 months.

How to Choose the Best Brand of Berberine

There are a couple of critical factors to consider when shopping for a quality berberine supplement. Fortunately, we have outlined a few of the essential elements you should look for in an effective berberine product.

Concentration and Purity

One of the critical things to remember while shopping for the right berberine supplement is purity. In our best berberine supplement reviews, we recommend avoiding products containing higher doses but poor concentration. Instead, go for low doses with higher concentrations. This way, you get a potent product at a great value.

Keep in mind that the product’s potency will likely be displayed in the form of a percentage. So, in other words, the higher the percentage, the more powerful the formula.

There’s a reason that our berberine supplement reviews consist of products that only contain this natural compound. We believe that a berberine supplement worth buying doesn’t contain additives, fillers, or ingredients that may be potentially harmful.

Dosage of Berberine

To receive the maximum benefits of berberine supplements, double-check the product label to ensure that you’re getting the correct dosage. Ingesting too much berberine can cause adverse effects such as gas, stomach cramps, and constipation. It’s also best to consult with your physician before taking any supplements.

Overall Value

The last thing you want to do is overspend when purchasing a new supplement. Therefore, there are a few things to consider when determining the overall value besides the final price. For instance, look at the concentration, the dosage and the number of servings per bottle. A quick and effective solution for this is to read other berberine supplement reviews online.

Finally, check if there are any ongoing deals on the official website and whether it offers free shipping. All of these things may potentially save you money.

Wrapping Up

Berberine is a natural plant compound with some researched-backed evidence of being a supplement for managing high blood sugar levels in individuals with type-2 diabetes and metabolic syndrome. It has properties to help regulate blood lipids and blood cholesterol and even help with weight loss.

Hopefully, these detailed berberine supplement reviews and our comprehensive guide will enable you to choose the most suitable supplement for your specific lifestyle.


What is the best source of berberine?

To recap, berberine is an alkaloid found in specific plants such as goldenseal, Oregon grape, European barberry, goldthread, tree turmeric, and Phellodendron. Please take a look at our reviews above to find out which supplement offers the best form of berberine for you.

Is it true that berberine kills good bacteria?

No, research shows that berberine does not kill good bacteria in the body but instead actually helps it. Based on a Medical Science Monitor paper from 2011, berberine alters probiotic bacteria levels in the body in a beneficial way.

Although the evidence on berberine supporting good bacteria is scarce, there isn’t any research showing that the supplement has adverse effects on the body’s gut microbiome.

Is berberine safe to take long term?

Based on clinical research, users can experience the benefits of berberine in up to eight weeks of continuous use. However, numerous studies have noted that these benefits may take up to twelve weeks.

It is unclear whether berberine is safe to take long term. Therefore, it’s always best to consult with a healthcare professional to find the best berberine supplement for your specific needs and body type.