Best Nootropics & Smart Drugs 2022 (Reviews & Buyer’s Guide)

Best Nootropics

The best nootropics are here to enhance your cognitive performance. Whether you need mental clarity or a memory boost—the benefits of nootropics are endless! 

To help you find the safest and most effective nootropic, we put together a list of the absolute best supplements based on the ingredients’ quality and variety, companies’ transparency, and value for money.

Let’s dive in!

An Overview of the Ten Best Nootropics

Key Features
Expert Review
  • The best premade nootropic stack
  • 11 research-backed ingredients
  • Full insight into dosages
  • No banned substances and no caffeine
  • Plant-based capsules
FROM: $ 69.00
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  • Eight brain boosters from the Amazon rainforest
  • Improves memory, mood, and energy
  • Third-party tests available on the main site
  • One of the safest nootropics
  • 1-year return policy
FROM: $ 54.95
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  • Supports brain health and cognitive skills
  • Helps with mental recovery
  • Allergen-free
  • Pills are made of fermented tapioca
  • 30-day performance promise
FROM: $ 49.00
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  • One of the best nootropics for memory
  • Improves verbal recall and focus
  • Gluten-and dairy-free
  • Clinically tested nootropic
  • Available in two sizes
FROM: $ 34.95
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  • Supports memory and cognition
  • Supports resilience and productivity
  • Over 5,000 positive global reviews
  • Affordable
  • 60-day refund policy
FROM: $ 18.99
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  • Natural and fast-acting
  • Boosts energy, focus, and motivation
  • The best nootropics for studying
  • Caffeine-free
  • 100% money-back guarantee
FROM: $ 22.19
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  • Supports cognition, focus, and memory
  • Helps with stress and anxiety
  • Rich in amino acids and B vitamins
  • Rigorously tested for quality and purity
  • Great value for money
FROM: $ 29.95
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  • Promotes mental clarity
  • Full transparency about its ingredients
  • Results supported by a pilot study
  • Favored by healthcare practitioners
  • 100-day money-back guarantee
FROM: $ 139.00
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  • Improves focus and cognition
  • Long-term effects
  • Formulated by neuroscientists
  • Potent, pure, and safe ingredients
  • Free worldwide shipping
FROM: $ 74.99
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  • Improves concentration and creativity
  • Best focus pills
  • No gluten, soy, preservatives, or synthetics
  • Developed in-house
  • Reputable manufacturer
FROM: $ 75.00
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Nootropics Reviews for Our Top Ten Choices

Mind Lab Pro

  • Rated: Best nootropic stack in 2022
  • Pills per Container: 60
  • Recommended Dosage: Two capsules a day
  • Price: $69.00
  • Discounts: Subscribe to the company’s newsletter to receive its limited time offers
  • Shipping and return policy: Free worldwide shipping on orders over $195.00; 60 days

Mind Lab Pro is one of the best and most effective all-in-one nootropics.  

Pure, clean, and caffeine-free, this nootropic stack is formulated with a total of 11 ingredients working together in six bio-pathways towards optimal brain performance.

In addition to the best neuroenhancers, like citicoline and phosphatidylserine (which may reduce the risk of dementia in the elderly, according to the FDA), the formula is crafted with a slew of vitamins and L-Tyrosine. The latter is an amino acid compound that aids mental performance in high-stress settings. 

All ingredients are scientifically proven to speed up reaction time and support mental performance.  What’s more, they’re highly bioavailable, sustainably sourced, and encapsulated in a 100% vegan, easy-to-absorb pill. 

Mind Lab Pro covers all facets of cognitive functioning. Nourishing and protecting the brain, it’s the best smart pill for professionals, students, athletes, and seniors—basically, anyone looking to boost memory, improve verbal communication, enhance motivation, and increase focus.

  • High-grade synergetic ingredients
  • 100% BrainPower (no fillers)
  • Third-party tested
  • Soy-free
  • Not the best choice for those looking for an extremely potent nootropic

Organixx Ageless Brain

  • Rated: Best organic brain booster
  • Pills per Container: 60
  • Recommended Dosage: Two capsules a day
  • Price: $54.95
  • Discounts: 10% with the subscription; sales
  • Shipping and return policy: Free on orders over $99.00; 1 year

Formulated with eight brain-boosting botanicals, sourced from the “world’s largest medicine cabinet”—the Amazon rainforest, Organixx Ageless Brain is one of the best nootropic pills for mental clarity and energy. 

Ingredients like Bacopa monnieri and cat’s claw lift the mood, boost memory, and promote new brain cell growth, while Pau d’Arco, guayusa, and other potent antioxidants protect the brain from inflammation, free radicals, and age-related cognitive decline.

Since all the core ingredients are organic, there is very little risk of side effects. Plus, this supplement is third-party tested for dangerous materials, and the reports are available on the site, assuring you that it’s safe to consume. 

Organixx is a trusted company manufacturing high-quality supplements—from the best turmeric pills to top-notch multivitamins. Their best nootropics come with many pros and very few cons, as verified by thousands of positive online reviews.

  • Vegan and free of pesticides
  • Made at an FDA-registered facility
  • Numerous discounts and sales
  • Soy-free
  • Some users say that they haven’t experienced much mental clarity

Performance Lab Mind

  • Rated: Best nootropic supplement for mental recovery
  • Pills per Container: 30
  • Recommended Dosage: One capsule a day
  • Price: $49.00
  • Discounts: Free bottle with a 3-month supply; discounts on multi-box purchases
  • Shipping and return policy: Free on orders over $200.00; 60 days

Performance Lab Mind is rated as one of the best nootropic supplements by numerous user and expert reviews. 

Crafted with just four incredibly effective ingredients, it improves all the elements of cognition: memory, focus, motivation, and energy. It also reduces stress, allowing the brain to recover faster from mental fatigue. 

Like Mind Lab Pro, this supplement contains Cognizin and Sharp-PS Green, in addition to Ajipure L-Tyrosine, which aids cognitive performance in the high-stress environment. Performance Lab Mind also contains maritime pine bark extract, which plays an integral role in cell regeneration. 

The list of nootropics in Mind incorporates compounds in the most advanced form possible for optimal absorption and maximum benefits. Even the pills themselves are good for you. Made from pullulan (fermented tapioca), they’re naturally prebiotic-infused. In other words, these capsules support digestion.  

With its comprehensive formula, Mind is a vegan, revolutionary nootropic you won’t regret trying.

  • No synthetic compounds
  • Helps brain recovery
  • Boosts brain energy up to 13.6%
  • Soy-free
  • No vitamins (must be combined with a vitamin supplement)
  • Delayed shipping due to popular demand

Onnit Alpha Brain

  • Rated: Best nootropic for memory
  • Pills per Container: 30 and 90 ct
  • Recommended Dosage: Two capsules a day
  • Price: $34.95–$79.95
  • Discounts: Subscriptions
  • Shipping and return policy: Free on orders over $150.00; 90 days

Not only is Alpha Brain one of the most popular nootropics, primarily thanks to Joe Rogan’s endorsement, it’s also one of the few nootropics that have been clinically tested.

Namely, an efficacy study was carried out in 2016. The study showed considerable improvement in verbal memory after just six weeks of taking Alpha Brain—proving the company’s claims of cognitive enhancement.  

Designed to target the most important aspects of brain optimization, Alpha Brain is formulated with three blends: 

  • Flow—to stimulate alpha brain wave production and improve attention span and reaction time
  • Focus—using the most powerful nootropic substances, like Alpha GPC, Bacopa monnieri, and huperzine A to support optimal acetylcholine levels, also known as the learning neurotransmitter 
  • Fuel—to maintain a healthy brain environment and improve neural communication

Alpha Brain is a stimulant-free, keto diet-friendly nootropic with clinically proven results. It comes as no wonder then that it’s been tried, tested, and recommended by over a thousand happy customers.

  • Caffeine-free
  • Keto-friendly
  • 90-day refund policy
  • Backed by an efficacy study
  • At times, results kick in after a few tries
  • Contains soy

Zhou Nutrition Neuro-Peak

  • Rated: Best value for money
  • Pills per Container: 30
  • Recommended Dosage: One capsule once or twice a day
  • Price: $18.99
  • Discounts: Subscriptions
  • Shipping and return policy: Free on orders over $30.00; 60 days

Neuro-Peak has been one of the top-selling and the best nootropics on the market for years. The simple reason behind its popularity is the straightforward, no-frills formula of six effective ingredients that work in absolute synergy to provide optimal cognitive performance. 

Now, when it comes to the Neuro-Peak’s ingredients, it’s worth noting that the supplement contains Ginkgo biloba for mental alertness and healthy brain function. There are also Bacopa monnieri, phosphatidylserine, and vitamin B12, which stimulate memory and cognition, as well as increase reaction time.  

Besides these potent nootropics, Neuro-Peak is formulated with 50mg of Rhodiola rosea, one of the best nootropics for mood, to help lower stress and keep you calm, focused, and motivated. 

Manufactured following the GMP regulations and tested by independent labs, this nootropic stack is perfect for anyone looking for a performance boost. On top of that, it’s reasonably priced and comes with a full 60-day risk-free trial—offering by far the best value for money on the market.

  • Made in the US
  • Third-party tested
  • Gluten-and GMO-free
  • 60-day risk-free trial
  • Vitamin B12 levels could be higher
  • Contains soy

Havasu Nutrition NeuroIGNITE

  • Rated: Best nootropic for energy and focus
  • Pills per Container: 30
  • Recommended Dosage: One capsule a day
  • Price: $22.19
  • Discounts: 25% off your first subscription order; 10% off all following subscription orders
  • Shipping and return policy: Free on orders over $35.00; 60 days

Get more focus, energy, and clarity with Havasu Nutrition NeuroIGNITE. 

This natural brain supplement and mood enhancer is formulated with 300mg of Bacopa monnieri, a nootropic known to boost multiple brain functions—from visual information processing to memory consolidation. 

Other ingredients include the natural nootropics Ginkgo biloba and phosphatidylserine; St. John’s wort, proven as an effective natural treatment against mild to moderate depression; as well as huperzine A and DMAE—both of which are reported to increase acetylcholine levels. 

Best of all, this fast-acting supplement doesn’t rely on caffeine to get the job done, so you won’t experience any coffee-induced jitters and anxiety. 

NeuroIGNITE may not be the most potent nootropic or have the most original formula, but it’s affordable, safe, and one of the best nootropics for focus, motivation, and energy, reviews say.

  • Over 3,000 positive reviews
  • Made at an FDA-registered facility
  • Third-party tested
  • 100% no-risk money-back guarantee
  • Contains soy
  • Dosage of core ingredients is low


  • Rated: Best nootropics for anxiety
  • Pills per Container: 60
  • Recommended Dosage: Two capsules a day
  • Price: $29.95
  • Discounts: Bundle deals and sales
  • Shipping and return policy: Not free; 30 days

Nootrogen is a great research-backed nootropic that supports cognition, focus, and memory. 

These smart drugs also help with everyday stress, especially performance-related anxiety, such as public speaking, academic testing, and similar high-pressure situations.  

The main ingredients in this nootropic stack are glutamic acid, an amino acid that works as a neurotransmitter, and L-Tyrosine—the precursor for dopamine and adrenaline, which boost motivation and energy. Nootrogen contains dimethylaminoethanol (DMAE) as well, believed to influence acetylcholine levels and increase the brain’s blood flow, thereby improving learning and memory. 

Other elements include trace minerals, like calcium, magnesium, zinc, and a vitamin B cocktail to stimulate the normal function of the brain. 

So, if you’re looking for powerful, safe, and cheap nootropics that can boost your concentration and confidence, Nootrogen is the product for you.

  • Provides advanced nourishment to the brain
  • Made at an FDA-registered facility
  • Great discounts on subscriptions
  • Slew of vitamins
  • Contains soy and fish
  • Lack of information regarding the company’s shipping policy

Neurohacker Collective Qualia Mind

  • Rated: Best nootropics for concentration
  • Pills per Container: 154
  • Recommended Dosage: Seven capsules a day / five days a week
  • Price: $139.00
  • Discounts: Subscription and sales
  • Shipping and return policy: Not free; 100 days

Qualia Mind’s advanced formula, developed by scientists in neurobiology and organic chemistry, is specifically crafted to provide optimal mental performance and boost long-term brain health.

Formulated with 28 clinically researched ingredients, these concentration drugs are said to promote neuroplasticity, provide metabolic support, and aid neuron and synapse development. 

In addition to widely used nootropics like Bacopa monnieri and Ginkgo biloba, Qualia Mind contains brain-boosting nutrients such as vitamins, DHA, and a wide range of antioxidants, amino acids, and choline precursors, i.e., compounds that increase acetylcholine levels.

Qualia Mind doesn’t just claim to make one of the best concentration pills—it can prove it. A 2018 pilot study showed a whopping 85.4% increase in concentration and the participants’ ability to avoid distractions, as well as an incredible 37.2% increase in planning skills.

  • All-natural ingredients
  • Gluten-and GMO-free
  • Trustworthy brand
  • Backed by an efficacy study
  • Serving of seven pills isn’t too practical
  • Quite expensive


  • Rated: Best nootropic for productivity
  • Pills per Container: 60
  • Recommended Dosage: Two capsules a day
  • Price: $74.99
  • Discounts: Sales and subscriptions
  • Shipping and return policy: Free worldwide shipping; 60 days

NooCube has one of the most advanced synergistic formulas on the market. Using a blend of seven potent vitamins, amino acids, and essential brain boosters, these top smart drugs can improve your concentration, reaction time, and overall cognitive function. 

The NooCube formula, designed by renowned neuroscientists, only contains the purest and safest ingredients. Each of the compounds has been rigorously tested. On top of that, their properties are supported by a ton of research. 

Some of these ingredients, like Alpha GPC and huperzine A, increase acetylcholine levels, while others, such as cat’s claw, protect the brain from Alzheimer’s disease and brain aging.

NooCube has fast-acting and long-lasting effects. Users report feeling the results for eight to ten hours—making it one of the strongest nootropics for tasks that need long-term focus, clarity, and motivation.

  • Clinically backed ingredients
  • No caffeine and GMO
  • Fast-acting
  • Developed by top neuroscientists
  • Alpha GPC levels could be higher
  • Only available on the main website

Roar Ambition Hunter Focus

  • Rated: Best nootropics for memory and focus
  • Pills per Container: 120
  • Recommended Dosage: Four capsules a day
  • Price: $75.00
  • Discounts: Bundle deals
  • Shipping and Return Policy: Free on orders over $80.00; 90 days

Hunter Focus is a nootropic supplement specifically crafted for determined men over 30 who want to stay in peak condition—physically and mentally. 

It contains nine natural ingredients formulated to help in three key areas, including:

  • Focus. Citicoline, a top nootropic used in the treatment of ADHD, works together with amino acids that increase dopamine production—allowing you to be alert yet collected. 
  • Memory. Both short-term recall and long-term memory retention are improved thanks to the combination of lion’s mane mushroom, maritime pine bark, and Bacopa monnieri.
  • Mood. Anti-anxiety ashwagandha and stress-reducing passion flowers are used to improve your mood and ensure that you’re at your best, even under pressure. 

All the ingredients in these mind-enhancing drugs have been chosen based on individual clinical studies, so you know you’re getting effectiveness, quality, and safety.

  • Ingredients are supported by valid research
  • Long-term effects
  • 90-day return policy
  • Nine potent ingredients
  • Incorrect information on the site regarding the number of capsules in a bottle
  • Not suitable for vegans and vegetarians

Your Guide to the Best Nootropics in 2022

By definition, nootropics are supplements that can increase cognitive function. These cover any natural or synthetic substances, from caffeine and fish oil supplements to prescription drugs that can improve mental performance and boost memory, focus, and creativity. The market for nootropics has been booming recently, which means that new products are coming out regularly, all of them promising to optimize brain performance.

How to pick the best smart drugs for you? Our guide is here to provide you with a couple of helpful tips. 

Define Your Goals 

The first step in choosing nootropics is evaluating your goals. Are you looking to improve your memory? Do you need more energy and motivation? Or are you going for total brain optimization? Once you have a clear idea of what you’re trying to get out of nootropics, you can start looking into the best cognitive enhancers.

For instance, if you need a boost of energy and concentration, try some of the top-rated caffeine supplements, or even better, a nootropic stack that combines caffeine and L-Theanine for even more mental energy. On the other hand, if you’re trying to memorize data for a big presentation, you might be better off with Bacopa monnieri, a well-known memory enhancer. This fantastic herb could also be effective in the treatment of Alzheimer’s and other age-related cognitive decline conditions. 

Single Ingredient or the Best Nootropics Stack?

When it comes to choosing nootropics, you have three choices: you can either opt for a single nootropic, such as Ginkgo biloba supplements or caffeine pills, combine two or more substances on your own, or buy a premade nootropic stack. All three options are effective; however, the last one is by far the most convenient and safest. Premade stacks are cost-effective, they combine multiple nootropics into one handy pill, and they’ll save you hours of researching the best combination of ingredients. Plus, they eliminate the danger of over or underdosing, while experimentation risks are minimized.

The Best Synthetic vs. the Best Natural Nootropics?

Most of the supplements out there contain natural components that have been used for thousands of years to increase brain power. However, many of them also incorporate synthetic compounds, such as Piracetam or Noopept. Whether you go for an “all-natural” cocktail, synthetic elements, or a combo of both, it’s entirely up to you as all options will get the job done. 

Dosage Recommendations

Determining the right dosage can be tricky. Take too much—you risk putting yourself in danger, take too little—you might not get the effect you’re after. The good news is that most of the nootropics on the market, including the ones mentioned in the nootropics’ reviews above, come with recommended dosages—taking the guesswork out of dosing. What’s more, these measurements are based on clinical trials and scientific studies carried out on particular nootropics in the blend, so there’s no risk of overdosing.  

Safety and Quality

Try to avoid products that contain fillers or coloring agents, and focus on purity and simplicity instead. With nootropics, less is more. Look for simple formulas, instead, containing clinically based ingredients and supportive elements like vitamins, antioxidants, and minerals. Bear in mind that even the latest, more advanced nootropics may contain allergens, like soy or nuts, so make sure you read the label for these supplements before making a purchase. 


When it comes to price, it’s important to note that almost all supplement companies offer subscription discounts, allowing you to save as much as 25% on your order. Combine this with a generous return policy, free shipping options, and other buying perks to get more bang for your buck. 

User Reviews

Check out more than one nootropics’ review by satisfied (and unsatisfied) customers before you make a final decision. User accounts and experience will provide you with plenty of information on the product’s efficacy, the right dosage, and the manufacturer’s reputation. 

Bottom Line 

The top-rated nootropics can be a great way to boost your memory, increase energy levels, and make you more alert, focused, and productive. However, like other supplements, nootropics should be taken responsibly and with caution. Consult a medical professional who will help you choose the best pills for you. And above all, trust your body. If you start to feel any side-effects or believe that the nootropic products are not working for you—stop using them.


What is the most effective nootropic?

Like the best multivitamin supplements, the most effective nootropic is one that combines several beneficial compounds into one convenient and functional nootropic stack. 

Who should buy nootropics?

Smart pills have gained a lot of popularity among students, CEOs, writers, and, generally, anyone who wants to improve their performance in a business, academic, or competitive setting. Nootropic drugs are also used by the elderly to enhance cognitive abilities and memory, as well as protect the brain from neurological aging.

Are nootropics safe?

Nootropics, like all other supplements, come with possible side effects, especially in the case of prescription medication such as Adderall or Ritalin. Nevertheless, if taken as recommended by either a manufacturer or a doctor, nootropics are generally safe to use.

Are nootropics natural?

The top nootropics generally fall into two categories—synthetic and natural. The former are lab-created substances such as Piracetam or Noopept, while the latter include herbs and extracts. Bacopa monnieri, Ginkgo biloba, and caffeine are some of the most widely used natural cognitive-boosting supplements.

What do nootropics do?

Nootropics can enhance your cognitive abilities, i.e., their effects range from improving short- and long-term memory to clearing up brain fog and boosting mental clarity. Some of the best nootropics support brain health and promote better communication between neurons, as well as increase the blood and oxygen circulation in the brain.