Western Diet Connected to Cognitive Decline in Mice

Western Diet Connected to Cognitive Decline in Mice

A recent study reveals that a Western diet may have a negative impact on the brain, resulting in cognitive dysfunction and neurodegeneration. The research team expects that the study’s results could offer possible treatment of neurodegenerative diseases. Neurodegenerative diseases can cause loss of structure and function of the central or peripheral nervous system. The most common diseases of this type are Alzheimer’s and Parkinson’s.

As per earlier research, poor diet and obesity can increase the risk of suffering from a neurodegenerative disorder. Moreover, a healthier diet could prevent or delay Alzheimer’s disease.

The Standard American Diet, or in other words, the typical Western diet, often consists of greater quantities of calorie-rich and high-fat foods with lower nutritional value. As per the new research, a typical Western diet can lead to cognitive decline and neurodegenerative issues through elevated Na,K-ATPase signaling in adipocytes or fat cells.

The study involved a gene-altered mouse model. The researchers fed the mice either a Western diet or a regular diet for 12 weeks. To activate NaKtide in the fat cells, the mice were also given doxycycline. The study’s authors noticed that the mice who were fed the Western diet had a significantly increased body weight compared to the mice who were eating a regular diet. Furthermore, the first group of mice had notable insulin resistance, lowered oxygen levels, and low energy.

A typical Western diet can lead to inflammation by increasing the type of cytokine molecules that promote it. If the body has too many inflammatory cytokines, it could develop certain diseases, such as neurodegenerative disorders. The study also discovered that the group of mice fed the Western diet had changes in behavior, gene expression, and signaling, similar to the changes in people with Alzheimer’s and Parkinson’s disease.

Nevertheless, the researchers want to conduct another research to try to replicate the present results in humans.


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