Best CoQ10 Supplements for 2022 (Reviews & Buyer’s Guide)

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Looking for the best CoQ10 product on the market can be a daunting task, and some of us simply don’t have the time (or the patience) to conduct hours of research. That’s why we gathered the best brands and supplements the market currently has to offer and made a comprehensive guide meant to help you find the best supplement for your needs.

Overview of the Most Effective Products

Product
Rating
Key Features
Website
OVERALL RATING
9.9
Expert Review
  • Improved absorption
  • Dairy- and wheat-free
  • Supports heart health
FROM: $ 22.80
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OVERALL RATING
9.7
Expert Review
  • Added shilajit for better absorption
  • Enhanced mitochondrial support
  • Patented ubiquinol formula
FROM: $ 15.00
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OVERALL RATING
9.5
Expert Review
  • Powerful antioxidant protection
  • Kaneka ubiquinol
  • Non-GMO
FROM: $ 11.33
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OVERALL RATING
9.8
Expert Review
  • Raw formula
  • Among the top-rated CoQ10 brands
  • Suitable for vegans
FROM: $ 39.89
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OVERALL RATING
9.6
Expert Review
  • USP-verified
  • Supports cellular energy production
  • No additives or preservatives
FROM: $ 35.24
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OVERALL RATING
9.5
Expert Review
  • Rapid-release formula
  • High-quality ingredients
  • Gluten-free
FROM: $ 17.44
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OVERALL RATING
9.3
Expert Review
  • Non-GMO
  • Potent antioxidant
  • Reputable brand
FROM: $ 33.97
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OVERALL RATING
9.2
Expert Review
  • Vegetarian formula
  • With Kaneka ubiquinol
  • Gluten-free
FROM: $ 20.66
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OVERALL RATING
9.3
Expert Review
  • Great variety of package sizes
  • CoQ10 in powder form
  • No additives or artificial flavors
FROM: $ 20.96
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OVERALL RATING
9.4
Expert Review
  • Gluten- and dairy-free
  • Suitable for vegans
  • KanekaQ10
FROM: $ 24.39
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Top CoQ10 Reviews

Qunol Ultra CoQ10

OVERALL RATING 9.9
  • Editor’s pick: Best fat- and water-soluble CoQ10 formulation
  • Form: Softgel
  • Doses per container: 100mg, 60 & 120 softgels
  • CoQ10 type: Ubiquinone
  • Shipping: Free on orders over $20.00 within the US
  • Price: From $22.80

Most experts will agree that Qunol is an outstanding supplement in the CoQ10 family. This water- and fat-soluble product is said to offer three times better absorption than regular CoQ10 and is viewed by many as the golden standard when it comes to these supplements.

This claim above seems to be backed up when we take a more thorough look at user reviews as well. People who have used this product state that it packs all the coenzyme Q10 benefits, providing more energy altogether, improving heart health, and helping them look and feel younger.

Taking everything into consideration, Qunol could be a fine addition to your supplement regimen, especially since it’s also available in a larger 120-softgel container, allowing you to save even more money. On the flip side, since it contains gelatin, this might not be the right CoQ10 to take if you are vegan or vegetarian.

PROS:
  • Provides a noticeable energy boost
  • Contains added vitamin E
  • Water- and fat-soluble
CONS:
  • Not suitable for vegans and vegetarians

Life Extension Super Ubiquinol CoQ10

OVERALL RATING 9.7
  • Editor’s pick: Top ubiquinol supplement with shilajit
  • Form: Softgel
  • Doses per container: 30, 60 & 100 softgels
  • CoQ10 type: Ubiquinol
  • Shipping: Fees apply
  • Price: From $15.00

Ideal for those who seek different doses and containers at different prices, Life Extension’s product also contains shilajit, which supports improved cellular energy output. The fact that this substance created by the decomposition of plants is also believed to have some potential in the prevention of Alzheimer’s makes this supplement a perfect choice for seniors.

When looking at users’ ubiquinol reviews, Life Extension’s supplement obviously garners a lot of positive feedback. A number of buyers discovered the product thanks to their doctor recommending it as a way to boost their energy levels, enhance mental acuity, or improve fertility, and most were happy with the results.

Some users did complain about the fact that the energy boost provided by this supplement occasionally kept them up at night if they took their dose before going to bed. Of course, if this happens to be the case for you, you can easily avoid the issue by taking the supplement earlier in the day.

Overall, if you’re looking for the most versatile coenzyme Q10 brand with the ubiquinol formula, this product might be a perfect fit, as it comes in different doses (50mg, 100mg, and 200mg) and different container sizes.

PROS:
  • Added shilajit
  • Increased bioavailability
  • Reputable brand
CONS:
  • May cause sleeping issues if taken late in the day

Natural Factors Ubiquinol Active CoQ10

OVERALL RATING 9.5
  • Editor’s pick: Top CoQ10 with Kaneka ubiquinol
  • Form: Softgel
  • Doses per container: 30, 60 & 120 softgels
  • CoQ10 type: Ubiquinol
  • Shipping: Free on orders over $20.00 within the US
  • Price: $11.33

When looking at the basic difference between CoQ10 and ubiquinol, brands and some experts usually mention that the latter form offers better absorption, especially for seniors. As such, some buyers tend to gravitate toward ubiquinol. Professionals also highlight the fact that only Kaneka-formulated raw materials make for the best ubiquinol products.

This Natural Factors supplement is exactly that, a Kaneka-formulated ubiquinol product that has also been lab-tested and said to be of guaranteed quality and potency. The quality of this particular supplement also shines through the stellar coenzyme Q10 reviews (provided by users and experts alike).

Those who speak highly of the product say that it gives them energy, it’s easy on the stomach, and that the softgels are easy to swallow. In one particular case, a user said that it even helped them with their varicose veins.

On the other hand, there were users who mentioned that the pills came stuck together. This seems to be caused by overheating during delivery, and while it might take some work to pry the softgels apart, their effectiveness shouldn’t be compromised. All in all, for those looking for quality, this Kaneka-backed product might be the perfect coenzyme Q10 supplement.

PROS:
  • Kaneka raw materials
  • Great variety of potency and container sizes
  • Added flaxseed oil for improved absorption
CONS:
  • Softgels can get stuck together in a clump during delivery

Garden of Life RAW CoQ10

OVERALL RATING 9.8
  • Editor's pick: Ideal vegan-friendly option
  • Form: Vegan capsules
  • Doses per container: 200mg, 60 capsules
  • CoQ10 type: Ubiquinone
  • Shipping: Free on orders over $20.00 within the US
  • Price: $39.89

If you’re looking for a vegan-friendly, kosher product that uses no synthetic fillers, colors, or additives, Garden of Life’s RAW CoQ10 might be the top CoQ10 supplement of 2022 for you. This whole food dietary supplement packs 200mg of CoQ10 in only one serving and comes with probiotics promoting greater digestive comfort.

The unique, fat-soluble RAW CoQ10 also features a specific lipid delivery system for better absorption that is based on the omega 3-6-9 matrix from cold-pressed chia seed oil. User reviews are overwhelmingly positive, with the most commonly reported benefits including improved physical performance, noticeable antioxidant effects, and better digestion.

Other, more critical CoQ10 supplement reviews stated that the capsules can get stuck to the cotton in the bottle, but untangling them is not an issue. All in all, if you’re looking for a 100% natural product that is suitable for people with various dietary restrictions, this supplement might be just what you’re looking for.

PROS:
  • Vegan-friendly
  • Added probiotics
  • Natural ingredients
CONS:
  • Capsules can stick to the cotton in the bottle

NatureMade CoQ10

OVERALL RATING 9.6
  • Editor’s pick: Best CoQ10 for budget buyers
  • Form: Softgel
  • Doses per container: 200mg, 105 softgels
  • CoQ10 type: Ubiquinone
  • Shipping: Free shipping available
  • Price: $35.24

Even though ubiquinone may not be the most optimal form of coenzyme Q10 in terms of absorption, there is no shortage of products based on it that became consumer-favorites thanks to their effectiveness. Nature Made CoQ10 is definitely one of them.

This USP-verified product contains no added colors, preservatives, or artificial flavors. It comes in different potency doses and container sizes at a fairly low price, and it has received almost exclusively positive user reviews. Some of the benefits that people who have used it for extended periods most often point out include the supplement’s effectiveness in supporting heart health, preventing statin-induced cramping, boosting energy levels, and reducing the likelihood of migraines.

While there has been some promising research investigating the effects of CoQ10 on blood pressure, reviews left by users rarely mention the supplement being effective in this regard, with some even reporting lack of results after prolonged use. However, since the product offers a wide range of other benefits, user impressions are still overwhelmingly positive. Finally, while some of the people who tried it did report they noticed a slight smell to the softgels, none of them considered this a major issue.

PROS:
  • Excellent price-to-quality ratio
  • USP-backed product
  • Over 5,500 positive ratings
CONS:
  • Softgels have a barely perceptible smell

21st Century Liquid Filled CoQ-10

OVERALL RATING 9.5
  • Editor's pick: Best rapid-acting CoQ10
  • Form: Softgel
  • Doses per container: 90 softgels
  • CoQ10 type: N/A
  • Shipping: Free on orders over $20.00 within the US
  • Price: From $17.44

You probably already know that the best time to take CoQ10 is between meals. Did you also know that alongside the food, rapid-release formulas might also help with better absorption? If you’re looking for a product that aims to do that at an amazing price, then you will need to try 21st Century’s Liquid Filled CoQ10 supplement.

The product is lab-tested, gluten-free, and it comes in either 100mg or 200mg doses, and 90 liquid-filled capsules in both cases. When reading liquid CoQ10 reviews, this 21st Century product does pretty well, with most buyers being satisfied with the price. In some cases, reviewers also stated that the supplement helped them relieve migraines, and others praised it for its energy-boosting properties.

Generally, people are pretty satisfied with the product at this price point. The gluten-free pills are easy to swallow, and most users are happy with the overall product quality. On the other hand, some reviews were critical of the fact that this supplement contains soy, but if you are not sensitive to this allergen, there’s nothing to worry about. Whether you’re taking CoQ10 for blood pressure or because of something else, at this price, this product might be the right place to start if you’re not looking to spend too much money right off the bat.

PROS:
  • Great price
  • Shown to help with migraines
  • Rapid-release capsules
CONS:
  • Contains soy

Nature’s Bounty Co Q-10

OVERALL RATING 9.3
  • Editor's pick: Top choice for cardiovascular health
  • Form: Softgel
  • Doses per container: 39, 75, 80 & 160 softgels
  • CoQ10 type: Ubiquinone
  • Shipping: Free on orders over $20.00 within the US
  • Price: From $33.97

If you are all about finding a potent CoQ10 supplement at a fair price, Nature’s Bounty probably has something to offer to you. This brand also sells CoQ10 in 400mg softgels, but a dose that high might be too much and not necessarily the best way to take CoQ10, as daily recommended dosages typically vary from 100mg to 200mg. If you’re considering supplementing with a product of this strength, make sure to consult your doctor first.

Apart from that, you get a laboratory-tested brand with years of experience on the market, at a price point that’s hard to pass up. User reviews are generally favorable for this supplement, meaning it didn’t land on our list of top-rated CoQ10 supplements without reason. Some reviews mention that this product helped a great deal with angina pectoris and heart problems overall, not to mention that it improved skin health in some customers as well.

On the other hand, some buyers did mention that the pills are large and hard to swallow, but this can hardly take away from the overall positive impression that this supplement otherwise leaves. All in all, if you are looking for a strong and potent product at a great price, Nature’s Bounty Co Q-10 might be exactly what you need.

PROS:
  • Large variety of package sizes and dosages
  • Supports skin health
  • Great quality-to-price ratio
CONS:
  • Pills might be too large for some

Bluebonnet Nutrition CellularActive CoQ10

OVERALL RATING 9.2
  • Editor's pick: Top CoQ10 supplement with a vegetarian formula
  • Form: Softgel
  • Doses per container: 60 softgels
  • CoQ10 type: Ubiquinol
  • Shipping: Free on orders over $20.00 within the US
  • Price: From $20.66

If you believe that ubiquinol is the superior form of CoQ10, then here’s a product that might be worth looking into. Bluebonnet Nutrition’s outstanding supplement comes in two doses (50mg and 100mg). In both cases, it uses Kaneka ubiquinol, which is essentially a seal of quality and reliability.

This might also be responsible for the higher price of the product when compared to other supplements on the list, but Kaneka is regarded as one of the best raw material suppliers when it comes to CoQ10 supplements and advancements.

When looking at CoQ10 reviews, most users are rather satisfied with the product, with some of them stating it gave them the stamina necessary for demanding activities within only a few days of taking it. Others mentioned improvements in sleep, less muscle pain, and overall better energy levels. On the other hand, some users mentioned side effects, like onsets of mild anxiety. However, these cases were rare, and lowering the dosage usually prevented further issues.

PROS:
  • Uses Kaneka ubiquinol
  • Highly potent
  • Suitable for vegetarians
CONS:
  • Mild side effects possible

Bulk Supplements Coenzyme Q10

OVERALL RATING 9.3
  • Editor's pick: Most versatile CoQ10 supplement size-wise
  • Form: Powder
  • Doses per container: 50 servings per 10g
  • CoQ10 type: Ubiquinone
  • Shipping: Free on orders over $59.00 within the contiguous US
  • Price: From $20.96

If you’re looking for the big guns, Bulk Supplement puts the “B” in “bulk” with their incredible offer, including everything up to a 55lb powder package. With a steeper price, some buyers probably won’t even take a second glance at the largest powder container, but it’s this variety that makes Bulk Supplements the top CoQ10 brand on our list in terms of package sizes.

On the other hand, for some, the fact that it contains ubiquinone might be a letdown. However, ubiquinone is the only variant of CoQ10 that can remain stable in powder form, making it the only choice for users who want to avoid softgels and capsules. Those who tried it stated that this particular product is of great quality and that it improved their overall wellbeing.

On a more negative note, some users mentioned that when it comes to price, CoQ10 and COVID “don’t mix,” as the pandemic drastically increased the price of these particular supplements. Likewise, there were some complaints about the powder being difficult to mix, but most users fixed this with a bit of coconut oil. Apart from that, most reviews are rather positive, so if you’re not a fan of softgels, this product might be your safest bet!

PROS:
  • Supports skin health
  • Several size options
  • Perfect for those who dislike softgels
CONS:
  • Powder can be difficult to mix

Solgar Vegetarian CoQ-10

OVERALL RATING 9.4
  • Editor's pick: Great kosher option
  • Form: Vegetable capsules
  • Doses per container: 60 & 180 capsules
  • CoQ10 type: Ubiquinone
  • Shipping: Free on orders over $20.00 within the US
  • Price: From $24.39

Solgar’s Vegetarian CoQ supplement comes in a variety of sizes and features Kaneka raw materials. Although it’s not a ubiquinol supplement, it boasts great absorption and will perfectly suit those customers looking for an active CoQ10 supplement from a reputable company.

This non-GMO product is said to improve heart health and promote healthy aging, with some even comparing its effectiveness to that of first-rate anti-aging creams. According to customer reviews, the supplement does a great job of that, keeping cellular health in check. That being said, some top CoQ10 supplement reviews did mention that the product can cause heartburn. Luckily, taking the supplement with meals as suggested should minimize the chances of this happening.

Apart from that, this is a quality supplement that’s worth looking into. Of course, before taking this or any other similar product, you should consult your doctor to clarify what your CoQ10 needs are.

PROS:
  • Kosher and suitable for vegans
  • Strong antioxidant
  • Non-GMO
CONS:
  • Some users found the capsule too big

How to Pick the Best CoQ10 Product for You

Now that you’ve had a look at our reviews, it’s time to learn a bit more about these supplements, and how to buy the right product for your needs.

About CoQ10, Ubiquinol, and Ubiquinone

Before we start, you should know that CoQ10 (ubiquinone) and ubiquinol supplements are practically the same in a way. Essentially, when you take CoQ10, both your ubiquinone and ubiquinol levels increase at some point. Because ubiquinone was stabilized first, most health experts will recommend it, simply due to the fact that it’s better researched.

On the other hand, taking a reliable ubiquinol supplement might be a superior way to go about things for many reasons. First, it’s the more absorbable form, and it has better overall bioavailability, enabling you to take smaller doses but reap the same benefits (this especially goes for seniors).

All this stems from the fact that CoQ10’s natural form is crystalline, which is by no means water-soluble. These crystalline compounds generally have difficulty absorbing in water. This is why ubiquinol and ubiquinone are typically modified for water-rich environments.

In some cases, this might be problematic for users, as they can’t be entirely sure if the coenzyme Q10 ubiquinol or ubiquinone product they bought is actually a properly formulated supplement. When it comes to formulation, there are several different versions of CoQ10 supplements, and most of them are marketed with “superior absorption” as their main selling point.

These can be:

  • Nano-technology: Small particles are used to boost absorption. So far, there are professional sources that are still suspicious about the actual effectiveness of these methods because reports on the subject are rather inconsistent.
  • Crystal-free: Any formulation aside from the original crystalline.
  • Liquid CoQ10: The crystals are combined with oil to promote absorption.
  • Water-soluble CoQ10: These products increase the surface area of powders and dissolve them in water.

Because there are tons of different options, expert advice on what to use will also vary. Some high-profile CoQ10 reviews encourage buyers to use the Kaneka-formulated products. As this Japanese company was the first to stabilize ubiquinol, some professionals will recommend mostly buying products from companies that have Kaneka as their raw material supplier. Apart from stabilizing the compound, Kaneka also studied ubiquinol quite rigorously and has the data pool to back their claims up.

Why Should I Take CoQ10?

When assessing the potential CoQ10 benefits for men and women, we should start with the fact that most healthy adults have adequate levels of the compound occurring in their bodies naturally, but with age, those levels tend to drop.

CoQ10 studies show that it may help improve blood pressure, ease heart conditions, and lessen the possibility of cardiac problems in the future. Likewise, there’s some evidence that the compound may help with muscle pains. Finally, preliminary studies also seem to show that CoQ10 may slow down the progression of Alzheimer’s, but there’s still much research to do in this field to come to a conclusive answer.

Higher coenzyme Q10 doses have also been used to effectively treat migraine headaches, though the treatment itself can take months to show effects. Lastly, studies also looked at whether the compound can be beneficial against diseases and conditions such as HIV, cancer, gum disease, muscular dystrophy, and several other conditions but with no conclusive answers so far.

CoQ10 and Fertility in Female and Male Adults

Female fertility usually starts to drop after 35, mostly because the egg quality in the reproductive organs tends to naturally decrease with age. At the same time, CoQ10 levels also tend to decline throughout the female body, which is why some experts prescribe CoQ10 supplementation for women older than 35 to replenish the decreased levels.

So far, the studies that have been assessing the links between CoQ10, fertility, and egg quality show that supplementation may lead to improvements in embryo and egg quality, along with better pregnancy outcomes.

In the case of male fertility, regular CoQ10 supplementation (just like high-quality ashwagandha products) may also improve overall fertility chances, mostly by increasing sperm motility. Being a powerful antioxidant, a potent CoQ10 for fertility may also act as an ally that can protect sperm from oxidative stress. According to a scientific review from 2018, the compound improved sperm motility, count, and concentration.

Dietary CoQ10 Sources

Most experts will agree that for healthy people, going straight to supplements shouldn’t be the first choice. Instead, they can always try focusing on nutrient-rich foods. However, in the case of this particular compound, top-quality CoQ10 supplements could actually be a good starting point, because CoQ10 is found in foods in only low amounts.

The highest concentrations are found in organ meats from chicken, pigs, and cows. It’s less concentrated in actual animal flesh. The amount you get from chicken thighs is almost the same as you would get from nuts and vegetables. For vegans, soybean, olive, and grapeseed oil would be the best sources, as they are also rather rich in the compound.

The problem is, to get around 100mg of CoQ10, you would need to consume half a pound of beef heart. So, food might not be the optimal form of CoQ10 intake to meet your needs.

CoQ10 Products – The Basics

Here are some of the most obvious steps you should take before opting for a product.

  • Checking the source: What we mean by this is always look for lab-tested products from brands with a trackable record. As these supplements aren’t FDA-regulated, be a bit more cautious and make sure that you are buying from reputable brands with solid reviews from experts and consumers alike. Always check the company, the ingredient list (even in the case of the highest-quality CoQ10 supplements), and make sure to consult your doctor before you start supplementing.
  • Checking the dosages: This can be especially handy when you’re comparing prices as there can be more obvious differences between supplements with higher versus those with lower dosages. However, with higher dosages, you might also notice more side effects, so make sure to keep your health in mind when looking for the best product. As such, if you have no underlying medical conditions, your optimal daily doses might be within the typical 100mg–200mg range.
  • Absorption rate: You should always take a thorough look at the ingredients to see whether the supplement contains additions like black pepper or shilajit, which are believed to improve absorption rates.
  • Study other ingredients as well: While this mostly depends on personal preference, you can always look into the ingredient list to see whether you can enjoy other benefits apart from the expected positive effects of your preferred premium CoQ10 supplement. For instance, supplements with added vitamin E might help you improve blood, brain, and skin health even further. Of course, you can always simply take high-quality multivitamin products independently of CoQ10.

CoQ10 and Dietary Restrictions

In most cases, you should have no issues with taking CoQ10 supplements unless your doctor advises you otherwise. However, you should know that the active ingredients in ubiquinol supplements are usually cultivated from yeast. Of course, you should always check whether the product you’re aiming to buy contains GMO, animal products, gluten, nut allergens, and soy.

Also, you need to know that ubiquinol has to be combined with inactive ingredients to be formed into supplemental products and that you will probably come across different brands that may use beeswax or gelatin, which might be a problem for those who follow vegan or kosher diets.

Downsides and Potential Side Effects

Even a first-rate brand of CoQ10 supplements might cause some side effects, the most common ones being heartburn, appetite loss, diarrhea, and nausea. However, these happen rarely, in around 1% of cases. Interactions with medications and other prescription drugs haven’t been looked at that thoroughly yet, with the exception of a handful of scientific studies mostly focusing on the interactions with warfarin. The indications are that CoQ10 might make this blood-thinning drug less effective.

Conclusion

That would conclude our reviews of the top-rated CoQ10 products. Hopefully, we have helped you learn more about the compound and to, ultimately, make a purchasing decision.

We understand that a lot of different factors go into choosing the product that matches your needs the most, which is why we did the legwork and examined some of the best supplements on the market. As you can see, CoQ10 plays a vital role in keeping our bodies healthy, and as such, choosing the best product for your needs can benefit you greatly.

FAQs

Which CoQ10 is the most effective?

Professionals often say that ubiquinol is a better option than ubiquinone because it’s water-soluble and much more easily absorbed into the bloodstream (up to eight times).

Apart from that, there are some ubiquinol CoQ10 supplements that are also enriched with shilajit, a compound that further increases energy production efficiency, which is among the main functions of CoQ10. So, with this in mind, ubiquinol (preferably with shilajit) might be the better option. However, professionals still agree that taking ubiquinone is still several times better than not taking any CoQ10 product at all.

What brand of CoQ10 do doctors recommend?

Generally speaking, most healthcare professionals will recommend brands with superior absorption, so you get the most out of your supplementation. As such, some experts will recommend Qunol as it is among the best-absorbing CoQ10 products on the market.

What is the best form of CoQ10 for absorption?

Most experts will tell you that choosing ubiquinol will be the better option since it absorbs almost eight times better. Also, when enhanced with shilajit, these CoQ10 supplements can be even more efficient.

Which CoQ10 is better, ubiquinol or ubiquinone?

Ubiquinol is considered to be the “active” form of CoQ10. This can often lead to confusion in determining which is better and whether their differences matter in a clinical sense. Professionals often say that ubiquinone is the tried and true CoQ10 formula, the most studied form of the compound, as prior to 2008, studies were done with this form.

This all changed when Kaneka, the company initially introducing Q10 to the larger supplement market, managed to come up with a technology that enabled the encapsulation and commercial production of the reduced, electron-rich form, ubiquinol. The additional electrons make the compound more bioavailable, making it more suitable for older people.

What is the best form of coenzyme Q10?

As already stated above, most experts view ubiquinol as the best form of the compound; however, there are actually some professionals in the field who claim that ubiquinol isn’t always necessarily worth the added cost. They assume that, if an individual doesn’t have a problem with efficiently converting oxidized (ubiquinone) to reduced CoQ10 (ubiquinol), then both forms should provide the same positive effects.

Using specific products might be required in cases when patients have trouble obtaining high serum levels of the compound even after months of relatively high-dose supplementation. In these cases, switching might be a good idea, and this is when the best CoQ10 products come into the picture.